Synthesis of hexahydro-1H-pyrrolo[1,2-c]imidazole derivatives by sequential azomethine ylide cycloaddition and urea cyclization reactions

An efficient, diastereoselective route to 2, 5, 6, 7-tetra-substituted 1H-purrolo[1,2-c]imidazoles has been developed using azomethine ylide cycloaddition and urea cyclization reactions. Relative stereochemical assignments at the four contiguous pyrrolidine stereogenic centers were established by single-crystal X-ray analysis.