Polymorphisms of the ASIP gene and the haplotype are associated with fat deposition traits and fatty acid composition in Chinese Simmental steers
2019
Abstract. Unlike specific expression in the skin of wild mice, the agouti signaling
protein (ASIP) is expressed widely in the tissue of cattle, including
adipose and muscle tissue. Hence, it has been suggested that ASIP plays a role in bovine fat metabolism. An inserted L1-BT element was recently identified upstream of the
ASIP locus which led to an ectopic expression of ASIP mRNA
in cattle. In this study, we detected the indel of the L1-BT element at
g. −14 643 nt and three SNPs in introns of the ASIP gene
(g. −568 A > G, g. −554 A > T, and g. 4805A > T) in a Chinese
Simmental steer population. The association analysis between variants of
ASIP and economic traits showed that the homozygous genotype of L1-BT
element insertion, AA genotype of g. −568 A > G, and AT genotype of
g. 4805A > T were significantly correlated with carcass and fat-related
traits, such as live weight and back fat thickness. Moreover, three
haplotypes (H1: AT; H2: AA; H3: GT) were identified by linkage disequilibrium
analysis and formed six combined genotypes. Results indicated that Chinese
Simmental steers with an H1H2 combined genotype had a higher measured value of
fat-deposition-related traits ( p ), including thickness of back fat and
percentage of carcass fat coverage, but a lower content of linoleic acid and
α -linolenic acid ( p ). Individuals of an H3H3 combination had a lower
marbling score, perirenal fat weight, and carcass weight ( p ). This
suggests that these three SNPs and two combined haplotypes might be molecular
markers for beef cattle breeding selection.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
30
References
1
Citations
NaN
KQI