Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling

Inositol phosphates are widely produced in animal and plant tissues. Luo and colleagues demonstrate that the inositol phosphate InsP7 modulates membrane translocation of the kinase Akt and downstream phosphatidylinositol-(3,4,5)-trisphosphate signaling in neutrophils.