The Structures of Toxic Metabolites of Aspergillus candidus. I. The Compounds A and E, Cytotoxic p-Terphenyls

The metabolites, compounds A-E, were isolated from a toxic strain of Aspergillus candidus and the structures of the characteristic cytotoxic compounds A (terphenyllin) and E (deoxyterphenyllin) were elucidated to p-terphenyl derivatives (1 and 24) by spectral data, oxidation reactions, and synthesis of compound A trimethyl ether. The cytotoxicity of the compounds and the derivatives was also discussed.