Linezolide in complex treatment of XDR-TB patients

Objective: To assess efficiency of treatment of XDR TB patients with linezolide. Materials and methods: Treatment of 78 XDR TB patients, enrolled in this study, consisted besides chemotherapy of collapse therapy, additional albuminous nutrition, and also supporting therapy, aimed at prevention of possible side effects. All TB patients were treated with Cm, Mfx, Cs, PAS, Pto, Z, Amx/Clv and Clr. Patients were divided into two groups: main group included 44 patients who received complex treatment and linezolide in the dose of 600 mg per day during 6 months and the other group (controls) consisted of 34 patients receiving the same complex treatment without linezolide. Therapy results were assessed in 12 months by frequency of negativation of M. tuberculosis with a culture method and by clinical and X-ray dynamics of a treatment process. Results: Culture method confirmed that 77,3% of patients became cultures negative in 12 months in the main group and only 35,3% of patients in the group of controls (p Conclusion: Inclusion of linezolide into regimen of chemotherapy for XDR TB patients signifcantly increases efficiency of their treatment.