Cover Picture: Eur. J. Immunol. 6/10
2010
The cover image of this issue consists of confocal images of cytomegalovirus-infected human fibroblast cells stained for HLA-A2/pp65 complexes, taken from Makler et al. (pp. 1552–1565). In this article, the authors use antibodies that mimic TCR specificity to directly visualize the dynamics of antigen presentation in these cells. The authors show that, following infection, large intracellular pools of HLA-A2/pp65 complexes are localized to the Golgi. Interestingly, these large pools are sequestered inside infected cells and only a small portion of them are exported to the cell surface.
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