NEDD4 Negatively Regulates GITR via Ubiquitination in Immune Microenvironment of Melanoma
2019
Introduction
Melanoma is a common skin cancer that is usually associated with poor clinical outcomes. Recently, the immune checkpoint GITR has been identified as a promising target for immunotherapy of melanoma. In this study, we aimed to investigate the post-translational regulation mechanism of GITR in melanoma.
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