Pelvic and periaortic peritoneal closure or non-closure at lymphadenectomy in ovarian cancer: effects on morbidity and adhesion formation

Abstract The effects of pelvic and periaortic peritoneal closure or (non-closure) on morbidity and adhesion formation were prospectively compared in 102 patients with ovarian cancer who had undergone a pelvic and periaortic lymphadenectomy. Hysterectomy with bilateral salpingoophorectomy, bilateral pelvic and periaortic lymphadenectomy, omentectomy, appendectomy and lysis of pelvic adhesions for the standardization o initial adhesion scores was performed on all patients. The pelvic and periaortic peritoneum were re-approximated in group I ( n =50) patients, and left open in group II ( n =52) patients. The groups were similar for mean age, previous surgery, tumour histology and disease stage. Morbidity characteristics such as blood loss, transfusion rate, post-operative infectious and non-infectious complications, and total hospital stay were also similar. After six courses of PAC (cisplatin 50 mg/m 2 , Adriamycin 50 mg/m 2 , cyclophosphamide 500 mg/m 2 ) chemotherapy, all patients underwent a second-look laparotomy. Persistent cancer was detected in 49 of 102 (48.03%) patients. Adhesion scores were detected at the time of second-look laparotomy. Adhesion scores for group I (8.9±2.9) were significantly higher than the group II (peritoneum non-closure) (5.8±2.3) (P