Nanosized iron telluride for simultaneous nanomolar voltammetric determination of dopamine, uric acid, guanine and adenine

2019 
Nanocrystalline iron telluride (FeTe2) compound was synthesized chemically at room temperature from homogeneous solution of tartrate complexes of Fe3+ and Te4+ followed by reduction with sodium borohydride. Different techniques including XRD, FESEM, TEM studies were carried out for structural characteristics of as prepared metal chalcogenide material. XRD study revealed the successful formation of orthorhombic phase of FeTe2 nanoparticles (nps) with a diameter of 20 nm. Electrochemical studies were carried out by employing cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The cyclic voltammetric responses confirmed the efficiency of prepared FeTe2 modified graphite paste electrode (FeTe2/GP) towards electrocatalytic oxidation of dopamine (DA), uric acid (UA), guanine (GU) and adenine (AD) in comparison with graphite paste (bare GP) electrode. DPV results depicted the appearance of four well defined distinct oxidation peaks correspond to DA, UA, GU and AD with peak potentials separation of 146 mV (DA-UA), 413 mV (UA-GU) and 343 mV (GU-AD), when FeTe2/GP electrode was dipped into ternary mixture of biomolecules solution in presence of phosphate buffer at pH=6.This enables simultaneous determination of all four analytes. Under optimized experimental condition, FeTe2/GP exhibited wider linear ranges of 5 µM- 120 µM, 3 µM-120 µM, 1 µM- 160 µM, 3 µM-100 µM for DA, UA, GU and AD with detection limit (S/N=3) of 28 nM, 42 nM, 34 nM and 26 nMrespectively. Moreover, the as prepared sensor was successfully applied to the analysis of spiked biological and pharmaceutical samples.
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