Selective Detection of Brain Metastasis of Malignant Melanoma Using 18F-10B-L-Borono-Phenylalanine with Positron Emission Tomography

Selective neutron capture therapy (NCT) using specific dopa analog,10B-p-boronophenylalanine (10B-L-BPA) for malignant melanoma of the skin was developed and achieved many cures by Mishima and his group1,2. We had developed 18F-10B-L-Boronophenylalanine which can not only provide selective detection and three dimensional imaging, but also 10B concentration dynamics clinically using positron emission tomography (PET)3,4,5. The purpose of this study is to explore NCT of melanoma brain metastasis using this compound.