Observational Study of Intravenous Lacosamide in Patients with Convulsive Versus Non-Convulsive Status Epilepticus

Background and Objectives Status epilepticus (SE) is an important emergency situation associated with high morbidity and mortality. The goal of pharmacological therapy—rapid seizure termination—is only achieved in just over half of patients with first-line anti-epileptic drug (AED) therapy and many patients require second and higher lines of AEDs to achieve seizure termination; therefore, there is a clear need for more effective treatment options. Lacosamide is a relatively new AED and the intravenous formulation has shown promise for treatment of SE. The aim of the current study was to compare electroencephalographic (EEG) response and seizure termination with intravenous lacosamide (±other AEDs) in patients with convulsive versus non-convulsive SE, in a Spanish intensive care setting.