Glucocorticoid Antagonists and the Role of Glucocorticoids at the Resting and Stress State

Glucocorticoids act on almost all organs and tissues. Their levels are rarely constant, showing both pronounced circadian variations and/or a rise during stressful situations. It is thought that glucocorticoids evoke an adaptation to stress via a variety of mechanisms including mobilization of fuel for metabolism, enhancement of cardiovascular function, and production of euphoria or behavioral activation. Glucocorticoids also suppress the immune system. It has been argued that this effect helps prevent autoimmune activation following “fight or flight” situations that result in trauma and inflammation.