[Diagnostic value and influencing factors for amplitude-integrated EEG in brain injury in preterm infants].

Objective To study the diagnostic value and influencing factors for amplitude-integrated EEG(a EEG) in brain injury in preterm infants. Methods One hundred and sixteen preterm infants with a gestational age(GA) between 27 weeks and 36+6 weeks were enrolled as subjects. The a EEG scores of all preterm infants were obtained within 6 hours after birth. According to the diagnostic results, the 116 preterm infants were divided into two groups: brain injury(n=63) and non-brain injury(n=53). The risk factors for brain injury were evaluated using logistic regression analysis. According to the a EEG results, the 116 preterm infants were divided into two groups: normal a EEG(n=58) and abnormal a EEG(n=58). The influencing factors for a EEG results in preterm infants were determined using univariate analysis. Results The brain injury group had a significantly higher rate of abnormal a EEG than the non-brain injury group(83% vs 11%; P0.05). The infants in the brain injury group from two different GA subgroups(27-33+6 weeks and 34-36+6weeks) had significantly lower a EEG scores than the non-brain injury group from corresponding GA subgroups(P0.01). Logistic regression analysis showed that low GA(32 weeks), low birth weight(1 500 g), abnormal placenta, fetal membranes, and umbilical cord, and hypertension during pregnancy were high-risk factors for brain injury(P0.05). There were significant differences in GA, birth weight, abnormal placenta, fetal membranes, and umbilical cord, and hypertension during pregnancy between the normal and abnormal a EEG groups(P0.05). Conclusions The risk factors for brain injury are consistent with the influencing factors for a EEG results in preterm infants, suggesting that a EEG contributes to the early diagnosis of brain injury.