Rabbit electroretinograms evoked by 632.8nm laser flash stimuli
2012
The flash electroretinography is a standard electrophysiological method and widely employed in basic research and
ophthalmology clinics, of which the stimulus is usually white flash from dome stimulator. However, little is known about
the electroretinograms (ERGs) evoked by monochromatic laser flash stimuli. The goal of this research effort is to
quantify the ERGs of dark-adapted New Zealand rabbits elicited by He-Ne laser flash with wavelength 632.8 nm. The
flash field was a Maxwellian viewing disc with angular subtense of 8.5°, 13.3° or 20.2°. The stimulus duration was 12
ms, 22 ms, 70 ms or 220 ms. The laser flash power incident on the cornea varied from 2.2 nW through 22 mW. Under the
condition of 20 ms stimulus duration and 20.2° flash field, the ERG of New Zealand rabbit was compared with that of
Chinchilla gray rabbit. Results showed that for the ERG b-wave, with the increase of laser energy, the amplitude first
increased, then met a trough and finally increased again, the implicit time decreased first and then met a platform. While
for the ERG a-wave, the amplitude increased and the implicit time decreased monotonically. Longer stimulus duration
led to lower b-wave amplitude under equal flash power level. The flash field size showed limited effect on the ERG,
especially on the low energy end. As compared with the pigmented rabbit, the albino rabbit was more sensitive and the
threshold energy for b-wave excitation was about 10 times lower.
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