Genetic variations of Omi/HTRA2 in Chinese patients with Parkinson's disease.

Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder, with approximately 5–10% of PD cases being linked to genetic factors. The Htra serine peptidase 2 ( HTRA2 ) gene, also known as Omi , was found to be associated with PD in a cohort of German PD patients. However, subsequent studies have indicated that some variants of Omi/HTRA2 may not be related to PD. In order to investigate whether the Omi/HTRA2 gene is related to PD in Han Chinese PD patients, molecular analysis for the Omi/HTRA2 gene was performed in 404 Chinese PD patients and 504 normal individuals. Our present study revealed 2 novel variations. The IVS5 + 29T > A variant may be a risk factor for PD ( P