Discovery of Potent and Selective 7-Azaindole Isoindolinone-Based PI3Kγ Inhibitors

Dillon H. Miles,Xuelei Yan,Rhiannon Thomas-Tran,Jeremy Fournier,Ehesan U. Sharif,Samuel L. Drew,Guillaume Mata,Kenneth V. Lawson,Elaine Ginn,Kent Wong,Divyank Soni,Puja Dhanota,Stefan G. Shaqfeh,Cesar Meleza,Ada Chen,Amber Pham,Timothy Park,Debbie Swinarski,Jesus Banuelos,Ulrike Schindler,Matthew J. Walters,Nigel Walker,Xiaoning Zhao,Stephen W. Young,Jie Chen,Lixia Jin,Manmohan Reddy Leleti,Jay P. Powers,Jenna L. Jeffrey

Discovery of Potent and Selective 7-Azaindole Isoindolinone-Based PI3Kγ Inhibitors

2020

The successful application of immunotherapy in the treatment of cancer relies on effective engagement of immune cells in the tumor microenvironment. Phosphoinositide 3-kinase γ (PI3Kγ) is highly ex...

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Combinatorial chemistry
Chemistry

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