Chromosome aberration analysis of lymphocyte and cancer of primary lung cancer patients

Objective To analyse the unbalanced state of heredity material of squamous carcinoma,adenocarcinoma and other type of lung cancer,and to provide base for the studying of the mechanisms of lung cancar.Methods Peripheral lymphocytes of 50 lung cancer patients and 55 specimens of lung cancer from patients suffered from lung cancar were included in this study.G-banding technique was used to analyse the chromosome.Results The aberration rate of chromosome of the lymphocytes in 50 patients were 32%(16/50),which was significantly higher than those of the benigh disease group and the normal control group.The aberration rate of middle/late stage group(59.1%,13/22)was higher than that of the I/Ⅱ stage group(10.7%,3/28).Only 23 cases in the total 55 cases had good results in the detecting of the chromosome of lung cancer.In the squamous carcinoma group,the gain region were 3q(3/6),3ql3(1/6) and 12p(3/6),the loss region were 2q(3/6).In the adenocarcinoma group,the gain region were lq(5/6),5p(2/6),8q(2/6) and 12p(3/6),the loss region were 9q(4/6) and 10p(2/6).Conclusion The heredity material of squamous carcinoma,adenocarcinoma and other type of lung cancer were unbalanced.The extension and deletion of chromatosome was the base of the occurrence of different lung cancer.