Expression and significance of gene Rad52 in nasopharyngeal carcinoma

Objective:To investigate the expression and clinical significance of Rad52,a homologous recombination repair gene,in tissues of nasopharyngeal carcinoma(NPC).Method:The expression of Rad52was detected with three-step immunohistochemistry technique in tissues of 38NPC patients and which have the corresponding paracancerous tissues.All of the Rad52expression and clinical data(gender,age,clinical stage)were compared and analyzed to conclude the relationship between them.Result:The Rad52expressions were significantly different from NPC tissues to peri-NPC tissues(P0.05).It was found by Spearman analysis method that the Rad52expression decreased with patients' clinical stages(P0.05),but has no significant relationship with gender,age,recurrence,and lymphonode metastasis(P0.05).The expression of Rad52influenced the survival time of NPC patients significantly(P0.05).Conclusion:The Rad52expression can be a useful prognostic and treatment factor for NPC patients.