The Effect of 1.2mg Simvastatin Mouthwash on the Level of Interleukin-6 in Patients with Chronic Periodontitis

Various materials and methods are nowadays used as complementary therapies for leveling the root surface for the treatment of periodontal diseases. The present study was conducted to evaluate the efficacy of simvastatin mouthwash on the level of interleukin-6 as an inflammatory cytokine that is supposed to be effective in the development of chronic periodontitis. The present randomized, double-blind clinical trial was conducted on 40 patients with moderate to severe chronic periodontitis. Initially, scaling and leveling the root surfaces were conducted for all patients and necessary training was presented; subjects in the intervention group, in addition to scaling, received 1.2simvastatin mouthwash. The level of interleukin-6 was measured before and one month after intervention, and data was analyzed by SPSS using paired t-test and covariance analysis. After treatment, there turned out to be a significant decrease in the level of interleukin-6 in the intervention group compared to the control group (P <0.05). The findings of the present study showed an increase in the clinical efficacy of treatment of chronic periodontitis with oral administration of 1.2 mg simvastatin as complementary therapy with scaling and leveling of the root surface.