Triphytochemistry and effects of aqueous and hydro-ethanolic extracts of Spathodea campanulata P.beauv. (Bignoniaceae) on blood-sugar level and markers of pancreatitis in type 2 diabetic rats

The objective of this study was to perform triphytochemistry and to evaluate the effect of aqueous (AqE) and hydroethanol (EthE) extracts of Spathodeae campanulata on blood glucose and pancreatitis markers in streptozotocin (STZ) -induced diabetic male rats. S. campanulata P. beauv, is a plant belonging to the Bignoniaceae family which is traditionally used for the treatment of diabetes, malaria and schistosomiasis. In a first step, we performed triphytochemistry of the extracts which showed that the aqueous and hydroethanolic extracts of the barks are rich in polyphenols, flavonoids, saponosides, alkaloids, sterol-polyterpenes, tannins but relatively poor in quinones. In a second phase, this study consisted in evaluating the effects on glycaemia and markers of pancreatitis of AqE and EthE of S. campanulata administered to 46 male rats of the Wistar strain divided into 9 batches of four male rats made diabetic each by intraperitoneal injection of a single dose of 60 mg/kg/bw of STZ. After 28 days of treatment with 200, 400 and 800 mg/kg/bw of S. campanulata AqE and EthE, blood glucose, alpha amylase and lipase activities were significantly decreased with both extracts.