Cytotoxic effects of prevotella nigrescens on cultured cells

Infection of the dental pulp commonly occurs as a consequence of caries. Pulpal infections often progress to pulp necrosis and periapical lesion development with periapical bone destruction. The severity of pulpal/periapical inflammation has been directly correlated with the total microbial content within root canals, and with the length of time the periapical tissues were exposed to the infecting microorganisms. Microbial studies of endodontic infections have revealed that gramnegative anaerobic bacteria are the prominent microorganisms. Some combinations of bacterial species present in root canals are more pathogenic in inducing periapical inflammation and bone destruction. Species of Prevotella, Porphyromonas, Fusobacterium, and Peptostreptococcus are strongly linked to increased periapical destruction. Sunqvist et al identified 25 strains of black pigmented Bacteroides in 22 of 72 infected root canals and Jin-Soon Han, Eun-Sook Kim, Su-Jong Lee, Yong-Ouk You*, Kyung-Soo Han**, Mi-Kyung Im Department of Conservative Dentistry, College of Dentistry, Wonkwang University Department of Oral Biochemistry, College of Dentistry, Wonkwang University* Department of Oral Medicine, College of Dentistry, Wonkwang University** Cytotoxic Effects of Prevotella nigrescens on Cultured Cells