Genomic features defining exonic variants that modulate splicing
2010
Background
Single point mutations at both synonymous and non-synonymous positions within exons can have severe effects on gene function through disruption of splicing. Predicting these mutations in silico purely from the genomic sequence is difficult due to an incomplete understanding of the multiple factors that may be responsible. In addition, little is known about which computational prediction approaches, such as those involving exonic splicing enhancers and exonic splicing silencers, are most informative.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
151
References
97
Citations
NaN
KQI