Köpeklerde Uzun Süreli Östrusun Sa¤›t›m›nda Megestrol Acetate'›n Etkisi

Ozet: Bu Cal›flman›n materyalini yafllar› 1.5-6 aras›nda deiflen farkl› ›rktaki 22 adet kopek oluflturdu. Uzun sure ostrus gosteren ve vaginal ak›nt› bulunan kopeklerden oncelikle sal›kl› bir anemnez bilgi al›nd›, genel durum muayenesi ve vaginal smear yap›ld›. Tan›, anemnez, genel durum muayenesi ve vaginal smear sonucu vaginadaki sitolojik deiflimlere bak›larak konuldu. Uygulama oncesi ve sonras›nda vulvadaki odem derecesi, vaginal ak›nt›n›n rengi, miktar› ve vagina mukozas›ndaki renk deiflimleri, k›vr›mlar›n oluflumu ve vestibulumda toplanan sekret miktar› belirlendi. Uzun sureli ostrus tan›s› konulan kopeklere 25 mg megestrol acetate (Niagestine(, 25mg/ml, Novo) subkutan enjekte edildi. Tedaviyi izleyen 1 y›l icerisinde kopeklerde meme tumorveya reproduktif bir problemin oluflup oluflmad›¤› kay›t edildi. Uzun sureli ostruslar›n klinik bulgular›, uygulamay› izleyen 3-7 gun aras›nda ortadan kalkt›. Ak›nt›n›n kesilmesi ortalama 3.5(2.5 gunde gercekleflti. Bir kopekte ak›nt›, uygulamay› izleyen 15. gune kadar devam etti. Kopee ovariohysterektomi yap›ld›, operasyon sonucunda kopein saovaryumunda 4 tane kistik yap›ya rastlan›ld› ve bu kopein ak›nt›s› operasyonu izleyen 2. gunde kesildi. Kopeklerde vulva odemi ortalama 3.5-1.6 gunde ortadan kalkt›. Sonuc olarak kopeklerde uzayan ostruslarda megestrol acetate ›n dier tedavi yontemlerine bir alternatif olabilecei kan›s›na var›ld›. Effects of Megestrol Acetate Treatment on Dogs with Prolonged Estrus Abstract: A total of 22 dogs of different breeds with persistent estrus, between the ages of 1.5 and 6, were used. Diagnoses were made by anamnesis, general examination and vaginal smear. Vulvar edema, colour and volume of vaginal discharge, convolution of the mucosa and volume of secretion were recorded before and after treatment. Dogs were treated with 25 mg megestrol acetate (Niagestine, 25 mg/ml, Novo). Clinical manifestations disappeared within 3-7 days. Vaginal discharge ceased in 3.5-2.5 days and vulvar edema ceased in 3.5-1.6 days. In only one dog, the treatment was not effective after 15 days. The vulva was still swollen and vaginal cytologic features were consistent with estrus, and the dog was spayed. After ovariohysterectomy, 4 cystic structures were found on the right ovarium surface, and vaginal discharge ceased after 2 days. Endometritis occurred in only one dog within a years. Abnormal mammary growth did not occur. It was concluded that megestrol acetate can be used as an alternative treatment for dogs with persistent estrus.