A gene network regulated by the transcription factor VGLL3 as a promoter of sex-biased autoimmune diseases

Yun Liang,Lam C. Tsoi,Xianying Xing,Maria A. Beamer,William R. Swindell,Mrinal K. Sarkar,Celine C. Berthier,Philip E. Stuart,Paul W. Harms,Rajan P. Nair,James T. Elder,John J. Voorhees,J. Michelle Kahlenberg,Johann E. Gudjonsson

A gene network regulated by the transcription factor VGLL3 as a promoter of sex-biased autoimmune diseases

2017

Yun Liang
Lam C. Tsoi
Xianying Xing
Maria A. Beamer
William R. Swindell
Mrinal K. Sarkar
Celine C. Berthier
Philip E. Stuart
Paul W. Harms
Rajan P. Nair
James T. Elder
John J. Voorhees
J. Michelle Kahlenberg
Johann E. Gudjonsson

Various autoimmune diseases have sex-linked biases. Gudjonsson and colleagues find that the transcription factor VGLL3 is associated with a female-biased molecular signature linked to susceptibility to autoimmune disease.

Keywords:

Biology
Transcription factor
Gene
Autoimmune disease
Cancer research
Population
Gene expression profiling
Genome-wide association study
Immunology
Systemic lupus erythematosus
Transcriptome
Autoimmunity

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