Morphofunctional changes in the spleen in idiopathic thrombocytopenic purpura

: Morphofunctional changes in the spleen in this disease were assessed using a number of histological, histoenzymochemical, morphometric, cytological, and immunological methods. The study included 52 operatively removed spleens. Hyperplastic changes in the white pulp varying in different age groups were demonstrated. Irrespective of the age, an increase in the number of macrophages and a decrease in the number of rosette-forming cells in the spleen tissue were observed, indicating disorders in cooperation of cells of the immunocompetent system, immunodeficiency state.