Synthesis of 2-(2-Imino-2,3-dihydropyrido[3,2-e]-1,3-thiazin-(Z)-4-ylidene)acetamide Derivatives
2008
A facile two-step preparation of the title pyridothiazine derivatives starting from commercially available 2-chloro-6-methylpyridine-3-carbonitrile is described. The reaction of this nitrile with magnesium enolates of tertiary acetamides affords ( Z)-3-amino-3-(2-chloro-6-methylpyridin-3-yl)propenamide derivatives, which in turn are allowed to react with isothiocyanates in the presence of sodium hydride to give the desired products in satisfactory yields.
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