Synthesis of imidazo [1, 2-a]pyridine-chalcones as potent inhibitors against A549 cell line and their crystal studies

Abstract Trisubstituted imidazo [1,2-a]pyridines were synthesized, further it was engrossed into corresponding chalcones. Amongst, the crystal structures of 3b , 3f and 3i were well defined by single crystal XRD. All the compounds were screened against A549 Cell line using MTT assay, where the chalcones 3a, 3b, 3d, 3f, 3h and 3i showed significant activity with IC 50 range of 7 μg/ml-42 μg/ml. The validation of the potent compounds was done by docking into the protein complex (4ph9). Furthermore, their hemocompatibility was analyzed by in vitro hemolytic assay.