Effect of pomegranate peel extracts on oxidative stress in restrained mice

Objective: To observe the protective effects of pomegranate peel extracts on oxidative stress in restrained mice.Methods: The liver injury model was established under 18 h restraint stress in mice.The protective effects were evaluated by assessing alanine aminotransferase(ALT) GSH and Malondialdehyde(MDA)levels in plasma and antioxidant capacities of liver were measured by using oxygen radical Absorbance capacity(ORAC) assay.Results: Activities of ALT and levels of MDA were observed to decrease on pomegranate peel extracts treated mice as compared with restraint stress control group and antioxidant capacity in liver homogenization and the levels of GSH in plasma significantly increased as compared with restraint stress.Conclusion: The results indicate that pomegranate peel extracts exert protective effects on oxidative stress in mice loaded with restraint stress,which may be related to its free radical scavenging activity and lipid peroxidation inhibitory effect.