The simple synthesis of quinazoline-2,4-dione derivatives using Boc strategy

Abstract Quinazolinediones are particularly attractive pharmacophores because of their wide range of bioactivities. A convenient synthetic pathway to three-substituted quinazoline-2,4-dione derivatives was developed from substituted anthranilamide via carbonylation with Boc anhydride and then cyclization in the presence of the base sodium methoxide. Good to excellent yields have been achieved.