In vitro antimalarial activity of different inhibitors of the plasmodial isoprenoid synthesis pathway

ABSTRACT Previous studies have shown that fosmidomycin, risedronate, and nerolidol exert antimalarial activity in vitro . We included squalestatin, an inhibitor of the isoprenoid metabolism in Erwinia uredovora, and found that combinations of compounds which act on different targets of the plasmodial isoprenoid pathway possess important supra-additivity effects.