Prognostic analysis on primary duodenal adenocarcinoma

Objective To investigate the prognostic factors of primary duodenal adenocarcinoma. Methods The medical records of 67 patients with primary duodenal adenocarcinoma treated in our hospital from January 1990 to December 2005 were retrospectively analyzed.Prognostic factors were analyzed by univariable and multivariable analysis. Results Of the 67 patients,38 underwent curative resection and 29 underwent palliative resection.The overall 5-year survival rate was 22.4%.The survival was significantly higher in patients who underwent curative resection (5-year survival 39.5%) than that in those who underwent palliative resection (5-year survival 0)(P<0.05).Univariable analysis showed that T-stage,nodal metastasis and tumor stage had significant negative effects on the survival of patients who underwent curative resection.However,multivariable analysis revealed that T-stage and nodal metastasis were significantly associated with survival. Conclusions Curative resection may improve the survival.T-stage and lymph nodes metastasis are associated with decreased survival. Key words: Duodenal neoplasms; Surgical procedures; Prognosis