Role of NAD + and mitochondrial sirtuins in cardiac and renal diseases

Nicotinamide adenine dinucleotide (NAD+) depletion contributes to the pathogenesis of cardiac and renal diseases. Here, the authors review the roles of NAD+ in the heart and kidney and discuss the mechanisms by which NAD+ supplementation might have therapeutic efficacy, with a focus on the role of mitochondrial sirtuins.