Targeting S -adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A
2017
PF-9366 inhibits Mat2A by binding to an allosteric site that overlaps with the binding site of Mat2B, altering the active site and supporting a model in which Mat2B can be either an inhibitor or an activator of Mat2A, depending on methionine and SAM levels.
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