Characteristics of esophageal motility of different types of achalasia patients by high resolutionmanometry

Objective To investigate the dynamic changes in achalasia patients by using high resolution manometry （HRM）. Methods Twenty-four achalasia patients were enrolled for HRM examination and typing. The esophageal pressure of patients with different subtypes was analyzed. Chi-square test was used for count data analysis. Two independent samples t-test was used for measurement data. Results Among twenty-four achalasia patients, five patients were type Ⅰ and male- dominated, 18 patients were type Ⅲ and female was more than male, and only one male patient was type Ⅱ. The frequency of weight loss in type Ⅰ was higher than that of type Ⅱ （Z =6.97, P=0. 008）. The frequency of chest pain and food reflux in type I was higher than that of type Ⅱ （both P〉0.05）. The average distance from the nares to the upper edge of the lower esophageal sphincter （LES） with the electrode successfully inserted into the stomach was （44.9±3.3） cm and to the lower edge of the LES was （48.0±3.2） cm. The average LES length was （3. 1±0.7 ） cm, average intraabdominal LES length was （2. 1 ±0.5） cm. The average LES resting pressure was （34. 6±13.8） mm Hg （1 mm Hg= 0. 133 kPa） and the integrated relaxation pressure （IRP） was （31. 1± 12.0） mm Hg. Conclusion Esophageal manometry is the golden standard for achalasia diagnosis, and HRM may be a simple, direct-viewing and accurate method for accessing esophageal motor function. Key words: Esophageal achalasia~ Manometry~ Kinetics