Synthesis and antiproliferative activity of pyridinylcarbonylpyrimidines against melanoma cell line

Department of Pharmacy, College of Pharmacy, Hanyang University, Gyunggi-do 426-791, KoreaReceived January 3, 2011, Accepted February 7, 2011The synthesis of the series of pyrimidinylamines 1a-d and pyrimidinylureas 1e-u bearing a novel pyridinyl-carbonylpyrimidine scaffold and their antiproliferative activities against A375 human melanoma cell line weredescribed. Among them, three compounds 1e, 1h, and 1o showed superior antiproliferative activities toSorafenib (IC