Morphometry of synaptophysin immunoreactive ganglion cells in Auerbach plexus in patients with colorectal cancer. Is this a new prognostic factor
2004
In this and a companion paper we present immunohistochemical and ultrastructural data on hamsters
infected with the Echigo-1 strain of Creutzfeldt-Jakob disease. Ultrastructurally, two types of vacuoles were
readily discriminated in the brain: the grey matter vacuoles of spongiform change and intramyelin vacuoles.
The vacuoles were always membrane-bound; the membranes were single or double. The axons were
entirely missing from the plane of the sections or, if visible, were shrunken and attached to the innermost
layer of the myelin. It was noteworthy that some vacuoles indented cell bodies or processes and thus were
reminiscent of the intraneuronal vacuoles typical for natural scrapie, BSE and CWD in ungulates and
cervids but not of the vacuoles encountered in rodent models of scrapie and CJD. We also noticed vacuoles
distending myelinated fibres in which the axons had become dystrophic. Some axons underwent
Wallerian degeneration while others met the criteria for dystrophic neuritis. Both alterations existed in the
same areas. Typical dystrophic neurites contained abnormal subcellular organelles, mainly electron-dense
lysosomal inclusions. Other neurites contained numerous multi-vesicular bodies and autophagic vacuoles.
Nuclear paracrystalline rod-like inclusions were occasionally visible in neurons while other inclusions comprised
spiroplasma-like inclusions in synaptic boutons. The robust cellular reactions consisted of reactive
astrocytes and macrophages filled with cellular debris. It is of note that complex autophagic vacuoles were
observed in the cytoplasm of neurons.
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