555 - Contrast enhanced ultrasound for the localization of prostate cancer – correlation with radical prostatectomy specimens

Introduction & Objectives: Trans Rectal UltraSound (TRUS) is an affordable, portable and safe imaging platform well known to the urologist for prostate imaging. However, prostate cancer (PCa) cannot be visualized with Greyscale TRUS. In Contrast-Enhanced UltraSound (CEUS), an intravenous Ultrasound Contrast Agent (UCA) consisting of gas filled microbubbles is used to visualize PCa-associated vascular anomalies. Contrast-ultrasound dispersion imaging (CUDI) analyses the UCA dispersion patterns as the UCA spreads through the prostate, with the intention to objectify and simplify the interpretation of CEUS. The aim was to determine the value of 2D CEUS imaging and the additional value of CUDI derived parametric maps for the localization of significant PCa.