An octadentate bifunctional chelating agent for the development of stable zirconium-89 based molecular imaging probes

89Zr-based imaging agents hold great promise as novel radio-tracers in nuclear medicine. However, insufficient stability of currently used radiometal complexes in vivo is a safety concern for clinical applications. We herein report the first octadentate bifunctional chelating agent for the development of 89Zr-labelled (bio)conjugates with improved stability.