Enantioselective construction of the 8-azabicyclo[3.2.1]octane scaffold. Application to the synthesis of Tropane alkaloids

The 8-azabicyclo[3.2.1]octane scaffold is the central core of the family of tropane alkaloids, which display a wide array of interesting biological activities . As a consequence, research directed towards the preparation of this basic structure in a stereoselective manner has gathered the attention of many research groups worlwide across the years. Despite this, most of the approaches relay on the enantioselective construction of an acyclic starting material that contains all the required stereochemical information to allow the stereocontrolled formation ot the bicyclic scaffold. As an alternative, there is an important number of methodologies reported in which the stereochemical control is achieved directly on the same transformation that generates the 8-oxabicyclo[3.2.1]octane architecture. This review compiles the most relevant achievements in this area