Use of Inclusion Complex of Cyclodextrin with Ambenonium to Improve the Treatment of Anticholinesterase Poisoning
2013
The complex of ambenonium with methyl-β-cyclodextrin injected intramuscularly to rats caused more pronounced inhibition of acetylcholinesterase in erythrocyte and brain than free drug. The use of this complex as part of combined therapy signifi cantly reduces mortality in animals during experimental anticholinesterase poisoning in comparison with the controls.
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