Persistent Candida albicans Infection of A Cerebrospinal Fluid Shunt Infection Unresponsive to Amphotericin B Treatment Because of Increased Minimum Inhibitory Concentration

Ozet Enfeksiyon sant uygulamalarinda halen en sik gorulen komplikasyondur. Mantar enfeksiyonlari nadir olmakla birlikte ciddi morbidite ve mortalite ile iliskilidir. Premature yenidoganlarda ve beyin ameliyatlarindan sonra bu risk artar. Bu makalede, tedavi sirasinda artmis MIC degeri nedeniyle amphoterisin B tedavisine cevap vermeyip vorikonazol ile flusitozin tedavisine cevap veren beyin omurilik sivisi (BOS)’da tekrarlayan Candida albicans uremeleri ile giden sant enfeksiyonlu bir olgu sunulmustur. (J Pediatr Inf 2015; 9: 181-4) Anahtar kelimeler: Candida albicans, sant enfeksiyonu, amfoterisin B, minimal inhibisyon konsantrasyonu Abstract Infection is still the most common complication of shunt procedures in children. However fungal infection is considered to be rare, it is also associated with significant morbidity and mortality. The risk is increasing in premature neonates and after neurosurgery. Herein, we present a preterm neonate with persistant Candida albicans cerebrospinal fluid (CSF) shunt infection that was unresponsible to amphotericin B treatment due to increased minimal inhibitory concentration (MIC) during the therapy period and later which was treated by voriconazole plus flucytosine. (J Pediatr Inf 2015; 9: 181-4)