THE EFFECT OF BODY MASS INDEX ON THE OUTCOME OF IVF/ICSI CYCLES IN NON POLYCYSTIC OVARY SYNDROME WOMEN

Background: The aim of this study was to investigate the effect of body mass index (BMI) on the outcome of in vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI) cycles in non polycystic ovary syndrome (PCOs) women. Materials and Methods: In this cross sectional study, 287 infertile non PCOs women referred to Royan institute, Tehran, Iran between 2002 and 2003 were enrolled. Patients with age≥40 years old or BMI <20 Kg/m2 were excluded. All of patients underwent IVF or ICSI cycles. The outcome of assisted reproductive technology (ART) were compared between three groups: patients with 20≤ BMI≤25 (normal weight group); patients with 25< BMI≤30 (over weight) and patients with BMI more than 30 Kg/m2 (obese group). ANOVA, T test, Chi-square and logistic regression were used for analysis.P value less than 0.05 was considered as significant level. Results: One hundred thirty three (46.3%) subjects had normal BMI, 117 women (40.8%) were overweight and 37 women (12.9%) were obese. Obese group had lower pregnancy rate (13.5%) in comparision to normal (29.3%) and overweight (21.4%) groups although this difference was not statistically significant (p=0.09). Chi square analysis showed that normal weight women had significantly higher regular mensturation (p=0.02). The logestic regression analysis showed that BMI significantly affects on pregnancy rate of ART cycles in non PCOs women (p=0.038). Conclusion: The finding of this study suggested that in non PCOs women, BMI had independent adverse effect on the pregnancy rate of IVF/ICSI cycles.