Method for preparing nefazodone intermediate 2-phenoxyethylamine

2012 
The invention relates to a method for preparing a nefazodone intermediate 2-phenoxyethylamine. In existing synthesis methods, some materials are difficult to obtain; and the used reagents of some materials are complicated, the synthesis difficulty is large, and the methods are difficult to be industrialized. The technical scheme includes that the method for preparing the nefazodone intermediate 2-phenoxyethylamine comprises steps of reacting 2-phenoxyacetaldehyde with ammonia gas to obtain corresponding imine, and reducing the imine to obtain the target product 2-phenoxyethylamine. According to the method for preparing the nefazodone intermediate 2-phenoxyethylamine, the process route is simple and direct, materials are easy to obtain, the cost is low, and the method is provided with industrial values.
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