The Association between GSTM1, GSTT1 Genetic Variants and Gastric Carcinoma Susceptibility in Chinese: A Systematic Review Article.

Background: Glutathione S-transferases ( GSTs ) have been investigated as potential carcinoma susceptible genes. However, the relationship between GSTs ( GSTM1 , GSTT1 ) variants and gastric carcinoma (GC) risk has been controversial in Chinese population. Methods: A comprehensive literature search strategy (PubMed, Chinese Biomedical Database, Chinese National Knowledge Infrastructure, Wan fang Database, etc.) was launched. Crude odds ratios (ORs) and confidence intervals (95% CI) were applied to estimate the strength of the association. Results: Significant associations between GSTs genetic polymorphisms and GC were evidenced under random-effects model (OR GSTM1 =1.56, 95% CI: 1.39 to 1.76, I 2 =50.7%, P <0.0001; OR GSTT1 =1.24, 95% CI: 1.10 to 1.39, I 2 =43.6%, P =0.014; OR GSTM1-GSTT1 =1.51, 95% CI: 1.26 to 1.81, I 2 =59.7%, P =0.004). The pooled ORs were not qualitatively changed when any single study was omitted by sensitivity analysis. Conclusion: Our results indicated an increased GC risk in Chinese population with GSTM1 and GSTT1 null genotype and GSTM1-GSTT1 dual null genotype. Further multi-center studies are needed to investigate the gene-gene and gene-environment interactions on the susceptibility of GC.