Immunomodulating effect of magnetoinfrared laser therapy in children with chronic pyelonephritis

Aim. To determine the influence of magnetoinfrared laser therapy on the status of immunological reactivity in children with chronic pyelonephritis (CP). Materials and methods. One hundred thirty children aged 8 to12 years, suffering from relapsing course of chronic pyelonephritis, were observed. Group 1 (43 patients) received complex conventional therapy, group 2 (27 patients) – complex treatment, associated with magnetoinfrared laser therapy. The blood lymphocyte population and subpopulation, blood serum immunoglobulin and circulating immune complexes content, phagocytosis indices, blood serum cytokine content was studied in children with chronic pyelonephritis at the active stage of disease, at the partial and full clinicolaboratory remission stages. Results. The CP patients of group 1, who received complex conventional therapy, demonstrated a full, but not long clinicolaboratpory remission with preservation of marked changes in immunological reactivity parameters. In CP patients of group 2, who experienced complex treatment associated with magnetoinfrared laser therapy courses, there occurred full clinicolaboratory remission and normalization of immunological reactivity indices. Conclusions. The results of clinical observations and special studies demonstrate high clinical, immunomodulating and antirelapsing effects of complex treatment combined with magnetoinfrared laser therapy in children with chronic pyelonephritis.