New potent angiotensin II receptor antagonists containing phenylthiophenes and phenylfurans in place of the biphenyl moiety.

The biphenyl fragment of the potent angiotensin II receptor antagonist L-158,809 was replaced by a phenylthiophene and a phenylfuran moiety. Replacement of the tetrazole-bearing phenyl by a thiophene resulted in a small loss in binding affinity (< 3X). Replacement of the central phenyl ring by a 2,5-disubstituted thiophene resulted in a thousand fold loss of potency.