AVM Radiosurgery: Where is the Volume Limit?

To evaluate the role of radiosurgery for large AVM (nidus volume > 8 ml). 200 cerebral AVM patients treated by Gamma Knife radiosurgery constituted the study database. Of them, 90 had a nidus volume > 8 ml. 38 of the 90 patients who fulfilled the following criteria were enrolled in result analysis. They were either treated more than 24 months ago or proved cured at any time earlier than 24 months. Grades of the AVM were II/2, III/11, IV/20, V/5 (Spetzler-Martin grading system). Integrated stereotaxic MR and stereotaxic x-ray angiography were used for treatment guidance. Volumes of the AVM nidi of the 38 patients were 8∼26 ml, median 11 ml. The prescribed mean maximum and minimum irradiation doses to the delineated AVM nidi were 36 Gy and 18 Gy, respectively.21 patients were cured of AVM at 18∼36, mean 23 months, after radiosurgery. Almost complete obliteration occurred in 6 patients at 24∼46, mean 37 months, and subtotal obliteration occurred in 11 patients at 27∼60, mean 38 months, after radiosurgery. Ni...