Using Ganglioside Early to Treat Acute Stroke and The Effect of the Change in TNF-αand IL-6

Objective To discuss the ganglioside's mechanism for acute stroke by observing the ganglioside's treatment effect for acute stroke and their change in TNF-αand IL-6.Methods 78 patients with acute stroke in our hospital during January 2009 to January 2011 were randomly divided into control group and observation group.The control group was given brain anticoagulant treatments and the observation group was given ganglioside treatment.Observed the FM score and the concentration of TNF-αand IL-6 before and after treatment.Results Two groups' FM score of patients after treatment were significantly higher than that before treatment(P0.05),after treatment,the FM score of observation group patients were higher than that of control group(P0.05);Two groups' TNF-αand IL-6 of patients after treatment were significantly lower than those before treatment(P0.05),and after treatment,the TNF-αand IL-6 of observation group patients were lower than those of control group(P0.05).Conclusion The effect of the ganglioside' treatment is better,it maybe protect the brain by lowering TNF-αand IL-6.