ANTLER statistical analysis plan, Version 3, 16 January 2020

This analysis plan sets out the methods of analysing the predetermined primary, secondary and health economic outcomes for ANTLER, which will be reported in the National Institute for Health Research, Health Technology Assessment report at the end of the trial and also in the main peer review paper(s) to result from this randomised controlled trial. The analysis and reporting of this trial will conform to the CONSORT and CHEERS statements and the appropriate standard operating procedures written by Priment Clinical Trials Unit. Further information on this trial can be found in the protocol version 7.0 (26/11/2018). The protocol is stored on: S:\Pop_Health\PCPH_Priment\Projects\Current\CTIMPS\ANTLER\6. Protocol\ANTLER_protocol_v7_20181126.pdf.