Skeletal Muscle PPARδ Increases Acutely with Resistance Exercise Inversely Proportional to Body Fat Percentage

PurposePPARδ expression in skeletal muscle has been shown to increase in response to resistance exercise training in our laboratory. However, it is unclear whether PPARδ expression is affected by a single bout of resistance exercise. Since dyslipidemia is associated with excess body fat, we examined the relationship between the change of PPARδ content and percent body fat in response to one bout of whole body resistance exercise. MethodsEleven untrained young men (N=4) and women (N=7) performed one bout of whole body resistance exercise that included leg press and leg extension for emphasis on quadriceps femoris muscles. Body fat percentage was measured by DEXA before exercise. Muscle biopsies were performed on the vastus lateralis muscles 24 hours before and 24 hours after the exercise. Western Blotting was conducted to quantify the PPARδ content. ResultsWith body fat percentage as a covariate, PPARδ levels increased by 49.1% (p<0.001) after one bout of resistance exercise. The amount of changes in PPARδ...